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目的：探讨一氧化氮（NO）在戊四唑癫痫发病机制中的作用．方法：每天注射戊四唑建立大鼠癫痫模型，测定癫痫发作后大鼠大脑皮质、海马一氧化氮（NO）和一氧化氮合酶（NOS）活性变化．结果：癫痫发作后海马NO含量和NOS活性显著升高（P＜0.01）．结论：NO在戊四唑诱导的癫痫中具有致痫性．
Objective: To investigate the role of nitric oxide (NO) in the pathogenesis of pentylenetetrazol (epilepsy) epilepsy. Methods: Rats were injected daily with pentylenetetrazole to establish a rat epilepsy model to measure the changes of nitric oxide (NO) and nitric oxide synthase (NOS) activity in the cerebral cortex and hippocampus of rats after epileptic seizure. Results: The content of NO and the activity of NOS in hippocampus after epileptic seizure increased significantly (P <0.01). CONCLUSIONS: NO is epileptiform in pentylenetetrazol-induced epilepsy.