家族性高胆固醇血症(FH)病人LDL颗粒的 大小

• 作 者: 朱德玲
• 出 处: 国外医学.临床生物化学与检验学分册
• 发表日期: 1995年01期
• 关键词: LDL颗粒 FH 受体基因 紧密连锁 高脂蛋白血症 遗传因素 高胆固醇血症 还原酶抑制剂 危险增加 动脉粥祥硬化

LDL颗粒的大小和LDI胆固醇(LDL-C)浓度 是动脉粥样硬化发生的重要因素,而小的LDL颗粒使冠心病危险增加。近来报告,LDL颗粒大小是由遗传因素调节的,可能包括一种与LDL受体基因紧密连锁的基因。因为已知LDL受体基因异常是FH的主要原因,所以作者提出:(1)FH病人是否显示LDL颗粒大小异常,(2)FH病人用HMG-CoA还原酶抑制剂治疗是否可影响LDL颗粒大小。作者用聚丙烯酰胺梯度凝胶电泳法估计LDL颗粒大小,由196名正常血脂成人(35岁健康男性)

The size of LDL particles and the concentration of LDL cholesterol (LDL-C) are important factors in the development of atherosclerosis, whereas small LDL particles increase the risk of coronary heart disease. It has recently been reported that LDL particle size is regulated by genetic factors and may include a gene that is tightly linked to the LDL receptor gene. Because LDL receptor gene abnormalities are known to be the primary cause of FH, the authors propose: (1) whether FH patients show abnormal LDL particle size, (2) whether treatment with HMG-CoA reductase inhibitors in FH patients affects LDL particle size . The authors used polyacrylamide gradient gel electrophoresis to estimate LDL particle size, consisting of 196 normal lipid adults (35-year-old healthy males)