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目的了解海南地区不同性别非瓣膜病心房纤颤(NVAF)患者的病因,临床伴随疾病以及脑卒中发生的高危因素。方法将随机纳入的329名海南NVAF患者按男女性别进行队列分析。结果NVAF男、女两组的首要病因均为冠心病,次要病因在女性组为甲状腺机能亢进性心脏病(17.39%);在男性组为高血压性心脏病(10.75%)。两组NVAF患者脑卒中的发病率十分接近,但伴随疾病各有特点。脑卒中发生的独立危险因素在女性NVAF为高血压(P=0.003)和未抗栓治疗(P=0.028),在男性NVAF为高血压(P=0.004)、未抗栓治疗(P=0.049)和年龄(P=0.004)。结论海南地区女性和男性NVAF患者各自具有其动脉粥样硬化基础及发生脑卒中等血栓栓塞事件的临床伴随疾病特点。
Objective To understand the etiology, clinical accompanying diseases and risk factors of stroke in patients with non-valvular atrial fibrillation (NVAF) of different sexes in Hainan Province. Methods A total of 329 randomized patients with NVAF in Hainan cohort were analyzed by gender. Results The primary cause of NVAF was male and female. The secondary causes were hyperthyroidism (17.39%) in female and hypertensive heart disease (10.75%) in male. The incidence of stroke in the two groups of NVAF patients is very close, but with the characteristics of each disease. Independent risk factors for stroke were higher in women with NVAF (P = 0.003) and no antithrombotic treatment (P = 0.028), NVAF in men with hypertension (P = 0.004) and no antithrombotic treatment (P = 0.049) And age (P = 0.004). Conclusions Both female and male patients with NVAF in Hainan Province have their own characteristics of atherosclerotic basis and clinical accompanying diseases such as stroke and other thromboembolic events.