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目的:比较红细胞悬液换血疗法与全血换血疗法治疗新生儿红细胞6-磷酸葡萄糖脱氢酶(G-6-PD)缺乏溶血症的疗效观察换血后血液成份及其生化的变化。方法:采用回顾性分析方法,将新生儿G-6-PD缺乏溶血症患儿分为治疗组和观察组,治疗组18例采用红细胞悬液经外周动静脉同步换血,观察组14例采用全血经外周动静脉同步换血,观察两组换血前后胆红素、血液总蛋白、血细胞、生化、血气分析的变化,比较两组胆红素置换效果。结果:两组胆红素换出量经比较差异无显著性,治疗组换血前后红细胞含量显著升高,血细胞、生化、血气分析经比较差异无显著性。结论:红细胞悬液换血疗法治疗G-6-PD缺乏性溶血症是安全、有效的方法。
OBJECTIVE: To compare the therapeutic effect of transfusion of erythrocytes suspension with whole blood transfusion therapy on hemoglobin-6-phosphate dehydrogenase (G-6-PD) in the absence of hemolytic disease. Methods: The neonates with G-6-PD-deficient hemolytic disease were divided into treatment group and observation group by retrospective analysis method. Eighteen patients in the treatment group were treated with erythrocyte suspension by peripheral arteriovenous venous exchange, and 14 cases in observation group Blood exchange peripheral arterial and venous blood synchronously, the bilirubin, blood total protein, blood cells, biochemical and blood gas changes before and after transfusion were observed. The bilirubin replacement effect was compared between the two groups. Results: There was no significant difference in the amount of bilirubin exchange between the two groups. The content of erythrocytes in the treatment group before and after transposition of blood was significantly increased. There was no significant difference in blood cell, biochemical and blood gas analysis. Conclusion: Erythrocyte suspension transfusion therapy for G-6-PD deficiency hemolytic disease is a safe and effective method.