论文部分内容阅读
1988年以来,全世界使用生长激素(growth-hormone:GH)治疗的病人显著增多.迄今为止已观察到31例患者于治疗期间或治疗后发生了白血病,而且有2例发展为恶性.31例白血病人的地区分布为日本10例、美国10例、欧洲10例、加拿大1例.29例于1975年或以后开始GH治疗,28例于1984年或以后发生白血病.从GH治疗开始至白血病发病的平均时间为5.0年(0.2～18.8年).
A significant increase in patients treated with growth-hormone (GH) has been observed worldwide since 1981. Thirty-one patients have been observed to have leukemia during and after treatment, and two have developed malignancy.31 Leukemia is distributed in 10 cases in Japan, 10 cases in the United States, 10 cases in Europe and 1 case in Canada .29 cases started GH treatment after 1975 or later, and 28 cases developed leukemia after 1984 or later. From GH treatment to leukemia onset The average time was 5.0 years (0.2 to 18.8 years).