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目的：探讨大鼠肝硬化形成中和门奇断流术后门脉压力（简称PVP）、外周血和门脉血中甘胆酸（简称CGA）的变化。方法：用四氯化碳诱发大鼠肝硬化，然后行门奇断流术，在肝硬化形成过程中和门奇断流术后，测PVP、外周血和门脉血中CGA。结果：肝硬化早期PVP增高，外周血CGA增高，门脉血CGA降低。随肝硬化加重，PVI，和外周血CGA逐渐增高，门脉血CGA逐渐降低。断流术后肝硬化鼠外周血CGA增高，PVP和门脉血CGA无变化，正常鼠PVP、外周血和门脉血CGA均无变化。结论：外周血CGA能早期准确地反映肝细胞损伤情况，早期诊断肝硬化，还能判断肝硬化的严重程度和预后。断流术能维持PVP，对正常鼠肝功能影响小，但对肝硬化鼠的肝功能有损害。
Objective: To investigate the changes of portal vein pressure (PVP), peripheral blood and portal blood glycocholic acid (CGA) after cirrhosis of liver and portal dementia in rats. Methods: Cirrhosis of the liver was induced with carbon tetrachloride (CCl4), followed by portal dementia. PVP, CGA in peripheral blood and portal blood were measured during the formation of liver cirrhosis and after Menzied’s disconnection. Results: In the early stage of liver cirrhosis, the PVP increased, the CGA in the peripheral blood increased, and the portal blood CGA decreased. With the aggravation of liver cirrhosis, PVI, and CGA in peripheral blood increased gradually, portal blood CGA decreased gradually. There was no change of CGA in peripheral blood of cirrhotic rats after disconnection and no change of CGA in PVP and portal blood, PVP in peripheral blood and CGA in portal vein. Conclusion: CGA in peripheral blood can reflect hepatocellular injury accurately and accurately, diagnose cirrhosis early, and judge the severity and prognosis of cirrhosis. Power flow can maintain PVP, small effect on normal liver function, but liver damage in cirrhotic rats.