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AIM:To determine the relationship between proliferative diabetic retinopathy(PDRP) and plasma coenzyme Q10 CoQ10 concentration.METHODS:Patients with type 2 diabetes and PDRP were determined to be the case group(n=50).The control group was consist of healthy individuals(n=50).Plasma CoQ10 and malondialdehyde(MDA) levels were measured in both groups.RESULTS:Ubiquinone-10(CoenzymeQ10)levelsinPDRP and control subjects are 3.81±1.19μmol/L and 1.91±0.62μmol/L,respectively.Plasma MDA levels in PDRP and control subjects were 8.16±2μmol/L and 3.44±2.08μmol/L,respectively.Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68,respectively.CONCLUSION:The ratio of ubiquinol-10/ubiquinone10 is found lower in patients with PDRP.High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.
AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10 CoQ10 concentration. METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n = 50). The control group consisted of healthy individuals (n = 50) .Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups .RESULTS: Ubiquinone-10 (CoenzymeQ10) levelsinPDRP and control subjects were 3.81 ± 1.19μmol / L and 1.91 ± 0.62μmol / L, respectively.Plasma MDA levels in PDRP and control subjects were 8.16 ± 2 μmol / L and 3.44 ± 2.08 μmol / L, respectively. Ratio of Ubiquinol-10 / ubiquinone-10 in PDRP and control subjects were 0.26 ± 0.16 and 1.41 ± 0.68, respectively. CONCLUSION: The ratio of ubiquinol-10 / ubiquinone 10 is found lower in patients with PDRP. High levels of plasma ubiquinol-10 / ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.