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目的探讨托里透脓汤结合西医化疗治疗骨关节结核的疗效。方法选择湖南省胸科(结核病)医院2010-2014年收治的骨关节结核患者148例,随机分为两组,每组74例。对照组患者给予传统3HRZE/9-12HRE方案规范抗结核治疗,观察组患者在3HRZE/9-12HRE方案规范抗结核的基础上加用托里透脓汤治疗,1剂/d,1月为1疗程,服用3疗程。观察两组患者治疗前及治疗4周、8周、12周、24周、48周后症状体征评分、X线评分变化,记录患者基本痊愈时间及治疗期间不良反应情况。数据资料采用SPSS19.0统计学软件,计数资料采用百分率表示,组间比较采用χ~2检验,计量资料采用均数±标准差表示,组间比较采用独立样本t检验,以P<0.05为差异有统计学意义。结果两组治疗前症状体征评分、X线评分差异无统计学意义(P>0.05),治疗4周、8周、12周、24周、48周时观察组症状体征评分、X线评分、血沉明显低于对照组(P<0.05)。观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗中均未出现肝肾功能损害、中毒性休克等严重不良事件。结论托里透脓汤结合西医化疗治疗骨关节结核能有效改善患者症状体征,提高治疗效果,促进患者快速恢复,值得应用。
Objective To investigate the curative effect of Tori Thorough abscess combined with Western medicine in the treatment of osteoarticular tuberculosis. Methods 148 patients with tuberculosis of bone and joint tuberculosis in Hunan Thoracic (Tuberculosis) Hospital from 2010 to 2014 were randomly divided into two groups, 74 cases in each group. Patients in the control group were given conventional 3HRZE / 9-12HRE regimen for antituberculous therapy. Patients in the observation group were treated with TORRE Pus soup on the basis of 3HRZE / 9-12HRE regimen. Course of treatment, taking 3 courses. The symptom score and X-ray score before treatment, 4 weeks, 8 weeks, 12 weeks, 24 weeks and 48 weeks after treatment were observed. The patients’ basic recovery time and the adverse reactions during the treatment were recorded. The data were analyzed by SPSS 19.0 software. The count data was expressed as a percentage. The χ ~ 2 test was used to compare the data between groups. The measurement data were expressed as mean ± standard deviation. The independent sample t test was used to compare the data between groups. P <0.05 was used as the difference There is statistical significance. Results There was no significant difference between the two groups in symptom score and X-ray score before treatment (P> 0.05). Symptoms and signs, X-ray score, erythrocyte sedimentation rate in observation group at 4 weeks, 8 weeks, 12 weeks, 24 weeks and 48 weeks after treatment Significantly lower than the control group (P <0.05). The total effective rate in observation group was significantly higher than that in control group, the difference was statistically significant (P <0.05). There was no serious adverse events such as liver and kidney dysfunction and toxic shock in both groups. Conclusion Tory Tonic pus soup combined with Western medicine treatment of bone and joint tuberculosis can effectively improve the symptoms and signs of patients and improve the therapeutic effect and promote rapid recovery of patients, it is worth applying.