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以心肌氧自由基(OFR)浓度、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量为指标,观察了增龄对心肌自由基反应的影响。结果表明:(1)心肌OFR浓度随增龄上升,至13、17月龄时达到显著水平(P<0.05):(2)心肌SOD活性随增龄下降,至13、17月龄时达到显著水平(P<0.05);(3)心肌MDA含量随增龄而增加,至13、17月龄时增加显著(P<0.05,P<0.01);(4)老年小鼠(17月龄)心肌SOD活性与OFR浓度呈高度显著的负相关关系(P<0.01),而MDA含量与OFR浓度呈显著的正相关关系(P<0.05)。上述结果表明,随增龄心肌自由基损伤性因素(OFR—MDA)增加,而保护性因素(SOD)减弱,这可能是老化心脏在结构、功能、代谢方面发生衰退的原因之一。
The effects of aging on the myocardial free radical reaction were observed with OFR concentration, SOD activity and malondialdehyde (MDA) content as indexes. The results showed that: (1) OFR concentration in myocardium increased with age, reaching a significant level at 13 and 17 months of age (P <0.05): (2) SOD activity in myocardium decreased with age, reaching significant at 13 and 17 months (P <0.05, P <0.05). (3) The content of MDA in myocardium increased with age, and increased significantly at 13 and 17 months (P <0.05, P <0.01) There was a highly significant negative correlation between SOD activity and OFR concentration (P <0.01), but there was a significant positive correlation between MDA content and OFR concentration (P <0.05). The above results indicate that with the increase of free radical damage factor (OFR-MDA) and the decrease of protective factor (SOD), this may be one of the reasons for the structural, functional and metabolic decline of aged heart.