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小鼠腹腔巨噬细胞、兔主动脉平滑肌细胞和内皮细胞与LDL共同孵育均能引起LDL氧化修饰。在培养液中加入不同剂量的姜黄醇提取物，能对抗上述三种细胞对LDL的氧化修饰作用，当姜黄素浓度在4．3μmol／L时对巨噬细胞和平滑肌细胞引起LDL氧化的抑制达65％以上，而对内皮细胞引起的LDL氧化的抑制作用需要较大的剂量，当姜黄素浓度在34μmol／L时达到57％，并且有明显的量效关系。
Co-incubation of mouse peritoneal macrophages, rabbit aortic smooth muscle cells, and endothelial cells with LDL can cause LDL oxidation modification. The addition of different doses of curcumin extracts in the culture solution can counteract the oxidative modification of LDL by the above three types of cells. When the concentration of curcumin is 4.3 μmol/L, the inhibition of LDL oxidation by macrophages and smooth muscle cells is achieved. More than 65%, but the inhibition of endothelial cell-induced LDL oxidation requires a larger dose, when the concentration of curcumin at 34μmol / L reached 57%, and there is a clear dose-effect relationship.