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临床分别以dl-15甲基前列腺素F_(2α)合并R_(2323)(下称PGF_(2α)+R_(2323),dl-15甲基前列腺素F_(2α)(下称PGF_(2α))和R_(2323)用于抗早孕。本文对用药后流产的早期胎盘组织进行了肉眼和光镜的观察。结果发现主要改变在壁蜕膜,包括变性、坏死、充血、出血和水肿。PGF_(2α)+R_(2323)组和PGF_(2α)组蜕膜的改变显著。R_(2323)组改变不显著。蜕膜改变的显著程度与抗早孕成功率的高低是相一致的。PGF_(2α)+R_(2323)组抗早孕成功率较高(97.93%)可能是通过两药的协同作用所致。
(2α) + R_ (2323), dl-15 methyl prostaglandin F_ (2α) (hereinafter referred to as PGF_ (2α) ) And R2323 were used in anti-early pregnancy.The results of macroscopic and light microscope observation of early placenta abortion after medication showed that the main changes were in the decidua, including degeneration, necrosis, congestion, hemorrhage and edema.PGF_ ( (2323) group and PGF (2α) group, there was no significant change in R2323 group.The degree of decidua change was consistent with the success rate of anti-early pregnancy.2 The effect of PGF 2α ) + R2323 group had a higher success rate of anti-early pregnancy (97.93%) probably due to the synergistic effect of the two drugs.