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布屈嗪(budralazine,1)化学名4-甲基-3-戊烯-2-酮(1-酞嗪基)腙,是一安全有效的降血压药。作者曾报道其合成及中间体肼苯哒嗪盐酸盐(2)的工艺改进,本文再介绍布屈嗪最后一步缩合的的工艺改进。文献报道,1是由2和亚异丙基丙酮
Budralazine (1) 4-methyl-3-penten-2-one (1-phthalazinyl) hydrazone is a safe and effective antihypertensive drug. The authors have reported on the synthesis and the process improvement of the intermediate hydralazine hydrochloride (2). In this paper, the process improvement of the last step of the condensation of bucuremine will be described. The literature reports that 1 is composed of 2 and isopropylidene acetone