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前列腺素(PG)在整个孕期起重要作用,其含量改变可影响妊娠和分娩的正常进行。细胞因子能增加人蜕膜细胞PG产生,但对负性调节剂未见明确报道。为研究地塞米松和孕酮对白细胞介素1β(IL-1β)刺激PGE_2产生的影响及其对环氧酶1(COX-1)和COX-2作用,取未用过阿司匹林或消炎痛等抗炎药物且无病理状况的妊娠6～8周治疗性流产的孕妇蜕膜细胞,剪碎后用两步消化法处理,然后用透明质酸酶、胶原酶和DNA酶依次处理,用Percoll不连
Prostaglandin (PG) plays an important role throughout pregnancy, and changes in its content can affect normal pregnancy and childbirth. Cytokines can increase the production of PG in human decidual cells, but no negative regulators have been reported explicitly. In order to investigate the effect of dexamethasone and progesterone on the production of PGE 2 stimulated by IL-1β and its effect on cyclooxygenase 1 (COX-1) and COX-2, aspirin or indomethacin Anti-inflammatory drugs and no pathological conditions Pregnancy 6 to 8 weeks of therapeutic abortion of decidual cells of pregnant women, after two-step digestion and shearing, and then treated with hyaluronidase, collagenase and DNase sequentially treated with Percoll not even