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Michaelis-Menten型消除动力学(简称米氏型消除)是非线性药物动力学中较常见而重要的一类。乙醇、苯妥英、茶碱、水杨酸盐等的体内过程都具有这类动力学特性。在一次给药下,描述血药浓度C随时间t变化的动力学方程都是非线性微分方程。因而在多次给药下(临床药物治疗通常都需多次给药),相应的C-t方程难以导出。为拟订最佳剂量方案,必须了解在多次给药下,血药浓度达到稳定状态所需要的时间,以及稳态血药浓度的高低。作者导出了平均稳态浓度方程,以及达到稳态所需时间的计算公式。此外,提出了临床
Michaelis-Menten type elimination kinetics (referred to as Mie-type elimination) is a more common and important class of non-linear pharmacokinetics. In vivo processes such as ethanol, phenytoin, theophylline, salicylates and the like have such kinetic properties. Under a single dosing, the kinetic equations describing the change of plasma concentration C with time t are non-linear differential equations. Thus in multiple administration (clinical drug treatment usually require multiple administration), the corresponding C-t equation is difficult to export. In order to develop the optimal dosage regimen, it is necessary to know the time required for the plasma concentration to reach a steady state and the steady-state plasma concentration for multiple administrations. The authors derived the average steady state concentration equation and the formula for calculating the time required to reach steady state. In addition, the proposed clinical