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目的探讨周围型肺癌CT表现与血清细胞角蛋白19片段(CYFRA21-1)滴度的关系。资料与方法回顾性分析48例周围型肺癌CT表现与血清CYFRA21-1滴度资料,对比分析CT表现与血清CYFRA21-1滴度的关系。结果 28例瘤体直径≥3 cm肺癌血清CYFRA21-1滴度(7.24±3.50)ng/ml,20例瘤体直径<3 cm肺癌血清CYFRA21-1滴度(4.80±4.18)ng/ml,两组血清CYFRA21-1滴度差异有统计学意义(P<0.05)。4例伴有空洞肺癌血清CYFRA21-1滴度(8.39±4.14)ng/ml,44例无空洞肺癌血清CYFRA21-1滴度(6.13±4.00)ng/ml,两组血清CYFRA21-1滴度差异有统计学意义(P<0.001)。肺癌有无深“分叶征”、“胸膜凹陷征”、“毛刺征”、支气管气相、增强CT值≥20 HU、“空泡征”、“毛玻璃征”、肺门或纵隔淋巴结增大与其血清CYFRA21-1滴度差异无统计学意义(P>0.05)。结论肺癌瘤体大小和空洞与其血清CYFRA21-1滴度有一定关系,瘤体直径≥3 cm或伴有空洞的肺癌血清CYFRA21-1滴度较瘤体直径<3 cm或无空洞的肺癌高。
Objective To investigate the relationship between CT appearance and serum cytokeratin 19 fragment (CYFRA21-1) titer in peripheral lung cancer. Materials and Methods The CT findings and serum CYFRA21-1 titer in 48 cases of peripheral lung cancer were retrospectively analyzed. The relationship between CT findings and serum CYFRA21-1 titer was analyzed. Results Twenty-eight lung cancer serum CYFRA21-1 titers (7.24 ± 3.50) ng / ml were detected in 28 patients with tumor diameter> 3. cm, and the serum CYFRA21-1 titer was 4.80 ± 4.18 ng / ml The serum CYFRA21-1 titer had statistical significance (P <0.05). Serum CYFRA21-1 titers (8.39 ± 4.14) ng / ml in 4 cases with empty lung cancer and serum CYFRA21-1 titers (6.13 ± 4.00) ng / ml in 44 cases without lung cancer were significantly different between the two groups There was statistical significance (P <0.001). Lung cancer with or without deep “leaf sign”, “pleural indentation sign”, “burr sign”, bronchial gas phase, enhanced CT value ≥ 20 HU, “vacuole sign”, "frosted glass sign The hilar or mediastinal lymph nodes increased with the serum CYFRA21-1 titer difference was not statistically significant (P> 0.05). Conclusions The size and cavity of lung cancer have a certain relationship with the serum CYFRA21-1 titer. The titer of serum CYFRA21-1 in lung cancer with diameter ≥3 cm or with empty cavity is higher than that of tumor with diameter <3 cm or without cavity.