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目的 观察氟比洛芬酯注射液联合芬太尼注射液用于老年髋关节置换术自控镇痛的临床疗效及安全性.方法 将140例拟接受全麻下髋关节置换术老年患者随机分为对照组70例和试验组70例.对照组予以芬太尼1 mg,自控镇痛;试验组予以氟比洛芬酯50 mg+芬太尼1 mg,自控镇痛.比较2组患者的简易精神状态量表(MMSE)评分和药物不良反应的发生情况.结果 术后48 h,试验组和对照组的MMSE评分分别为(28.83 _±1.31)和(25.73±1.65)分,差异有统计学意义(P＜0.05).2组患者的药物不良反应以恶心、呕吐、皮肤瘙痒为主,试验组和对照组的药物不良反应发生率分别为8.57％和22.86％,差异有统计学意义(P＜0.05).结论 氟比洛芬酯注射液联合芬太尼注射液用于老年髋关节置换术的临床疗效确切,且安全性较好.“,”Objective To observe the clinical efficacy and safety of flurbiprofen axetil injection combined with fentanyl injection in the treatment of elderly hip replacement.Methods A total of 140 patients with elderly hip replacement were randomly divided into control group (n =70 cases) and treatment group (n =70 cases).Control group was given fentanyl 1 mg,patient-controlled analgesia.Treatment group was given flurbiprofen axetil 50 mg ± fentanyl 1 mg,patient-controlled analgesia.The mini-mental state examination (MMSE) scores and adverse drug reactions were compared between two groups.Results After operation 48 h,the MMSE scores of the treatment and control groups were (28.83 ± 1.31),(25.73 ± 1.65) points,with statistically significant difference (P ＜ 0.05).The adverse drug reactions in two groups were based on nausea,vomiting and skin itching.The incidences of adverse drug reactions in the treatment and control groups were 8.57％ and 22.86％ with significant difference (P ＜ 0.05).Conclusion Flurbiprofen axetil injection combined with fentanyl injection has a definitive clinical efficacy and safety in the treatment of elderly hip replacement.