Simultaneous LC-MS/MS Determination of Danshensu and Paeoniflorin for Permeability Studies in Caco-2

• 作 者: LIU Li ZHAO Xiao-ping ZHU Di-f
• 机 构: PharmaceuticalInformaticsInstitute,DepartmentofBasicMedicine
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2008年4期
• 关键词: 微透析 高性能液体色谱法 质谱法 渗透系数 LC-MS/MS 肠内吸收 中药 Denshensu Paeoniflorin Caco-2 cell Appare
• 基金项目: Supported by the National Basic Research Priorities Program of China（No. 2005CB523402）, the Natural Science Foundation of Zhejiang Province, China（No.Y204418） and the Program for New Century Excellent

A high sensitive method based on liquid chromatography tandem mass spectrometry(LC-MS/MS) was developed and validated for the study of permeability of danshensu(DS) and paeoniflorin(PF) in Caco-2 intestinal absorption model. The DS and PF were extracted f