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目的观察多潘立酮加阿米替林治疗功能性消化不良的疗效。方法对172例功能性消化不良患者随机分为治疗组96例,对照组76例。对照组患者给予多潘立酮10mg,3次/d口服治疗;治疗组在此基础上加用阿米替林12.5mg,早、中口服,晚睡前25mg口服。两组患者治疗4周。治疗结束时观察比较两组的症状改善情况,并于疗程结束3个月后随访,调查复发情况。结果治疗组疗效明显优于对照组,两组疗效差异有统计学意义(P<0.05)。两组均无严重的不良反应发生。结论多潘立酮联合阿米替林使用治疗功能性消化不良,疗效优于单用多潘立酮,且可降低复发率,值得临床应用推广。
Objective To observe the efficacy of domperidone plus amitriptyline in the treatment of functional dyspepsia. Methods A total of 172 patients with functional dyspepsia were randomly divided into treatment group (96 cases) and control group (76 cases). The patients in the control group were treated with domperidone 10 mg orally 3 times daily. The treatment group was given amitriptyline 12.5 mg on the basis of the above. Two groups of patients for 4 weeks. At the end of treatment, the symptoms of the two groups were observed and compared. The patients were followed up for 3 months after the end of treatment to investigate the recurrence. Results The treatment group was significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Domperidone combined with amitriptyline treatment of functional dyspepsia, the effect is superior to domperidone alone, and can reduce the recurrence rate, it is worth promoting the clinical application.