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目的研究家族趋化因子受体7(CXCR7)和血管内皮生长因子(VEGF)在人胃癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测60例胃癌组织(A组)和20例正常胃黏膜组织(B组)CXCR7和VEGF的蛋白表达,分析其与临床病理特征之间的关系。结果 A组CXCR7表达率为63%;B组未见CXCR7表达。A组VEGF表达率为70%,明显高于B组的10%(P<0.01)。A组胃癌侵及浆膜、低分化、有淋巴结转移和TMNⅢ-Ⅳ期组的CXCR7和VEGF表达均明显高于其未侵及浆膜、中分化、无淋巴结转移和TMNⅠ-Ⅱ期组(P<0.01或P<0.05)。A组CXCR7和VEGF的表达呈正相关(r=0.597,P<0.01)。结论胃癌组织CXCR7和VEGF均呈高表达,与其发生、发展过程密切相关。
Objective To study the expression of chemokine receptor 7 (CXCR7) and vascular endothelial growth factor (VEGF) in human gastric carcinoma and its clinical significance. Methods The expressions of CXCR7 and VEGF in 60 gastric cancer tissues (A group) and 20 normal gastric mucosa tissues (B group) were detected by immunohistochemistry. The relationship between the expression of CXCR7 and clinicopathological features was analyzed. Results The expression rate of CXCR7 in group A was 63%. The expression of CXCR7 in group B was not observed. The expression of VEGF in group A was 70%, which was significantly higher than that in group B (P <0.01). In group A, the expression of CXCR7 and VEGF in serosal invasion serosa, poorly differentiated, lymph node metastasis and TMNⅢ-Ⅳ group were significantly higher than those in non-invasion serosa, moderately differentiated, non-lymph node metastasis and TMNⅠ-Ⅱgroup <0.01 or P <0.05). A group CXCR7 and VEGF expression was positively correlated (r = 0.597, P <0.01). Conclusions The expression of CXCR7 and VEGF in gastric cancer is highly expressed, which is closely related to the occurrence and development of gastric cancer.