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目的观察血管紧张素Ⅱ受体拮抗剂坎地沙坦酯治疗早期糖尿病肾病(DN)患者的临床疗效。方法将57例合并微量白蛋白尿的糖尿病患者采用低蛋白饮食、控制血糖的同时,联合坎地沙坦酯治疗,并定期测定血压、糖化血红蛋白及尿白蛋白排泄率(UAER),与既往使用伊那普利治疗的48例DN患者做比较。结果两组患者血糖、血压无明显差别;治疗组UAER减少程度好于对照组,具有统计学意义;治疗组病人的耐受性也好于对照组。结论坎地沙坦酯是临床治疗DN的良好选择。
Objective To observe the clinical effect of candesartan cilexetil, an angiotensin Ⅱ receptor antagonist, on patients with early diabetic nephropathy (DN). Methods Fifty-seven diabetic patients with microalbuminuria were treated with candesartan cilexetil and low-protein diet to control blood sugar. Blood pressure, HbA1c and urinary albumin excretion rate (UAER) were measured regularly. Compared with previous use Forty-eight patients with DN treated with enalapril were compared. Results There was no significant difference in blood glucose and blood pressure between the two groups. The reduction of UAER in the treatment group was better than that in the control group, which was statistically significant. The tolerability of the treatment group was also better than that of the control group. Conclusion Candesartan cilexetil is a good choice for clinical treatment of DN.