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结直肠癌是目前世界范围内致死率极高的一种恶性肿瘤,发病率呈逐年上升的趋势。当v-Ki-ras2 Kirsten大鼠肉瘤病毒癌基因同源物(v-Ki-ras2Kirsten rat sarcoma viral oncogene homolog,K-Ras)基因突变时患者极易出现复发和转移,严重影响了直结肠癌的治疗进程。耐药是肿瘤治疗中的主要问题,K-Ras基因突变型直结肠癌的耐药问题尤其突出,且目前缺少有效的治疗对策。随着对K-Ras基因突变后,肿瘤耐药、复发和转移机制研究的增多,直结肠癌分子标志物不断被发现,新型药物及相应的联合用药方案不断出现,K-Ras突变型直结肠癌的治疗也愈来愈趋向合理化,但其中仍存在许多问题。因此,本文将就K-Ras突变型结直肠癌的研究近况,从其突变特征、治疗难点、研究突破和未来预测等方面对K-Ras基因突变型直结肠癌的研究进展进行综述,希望能为后续临床治疗和研究提供一些有用参考。
Colorectal cancer is a kind of malignant tumor with extremely high lethal rate in the world at present, and its incidence is increasing year by year. When the gene mutation of v-Ki-ras2 Kirsten rat Kirsten rat K-Ras gene is very prone to recurrence and metastasis, it has a serious impact on the expression of Treatment process. Drug resistance is a major problem in cancer therapy. The drug resistance of K-Ras gene mutation type colon cancer is particularly prominent, and there are currently no effective treatment strategies. With the increase of the drug resistance, relapse and metastasis mechanisms of K-Ras gene, molecular markers of colorectal cancer have been found continuously, new drugs and the corresponding combination regimens continue to emerge, K-Ras mutant enterocolitis The treatment of cancer is also more and more rationalization, but there are still many problems. Therefore, this article reviews the recent progress of K-Ras mutant colorectal cancer, and reviews the progress of K-Ras mutant human colon cancer from its mutation characteristics, treatment difficulties, research breakthroughs and future predictions For follow-up clinical treatment and research to provide some useful reference.