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目的探讨孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的疗效。方法选取唐山市丰润区人民医院确诊收治的84例咳嗽性变异性哮喘患儿作为本研究对象,随机分为观察组和对照组,其中,对照组40例采用布地奈德治疗,观察组44例采用孟鲁司特钠联合布地奈德治疗,对比两组治疗3个月后的肺功能治疗指标、治疗有效率、复发率以及用药治疗过程中不良反应发生情况。结果观察组治疗后的肺功能指标第1 s用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC、日间及夜间最大呼气流速(PEF)水平改善情况、治疗有效率(93.18%)及复发率(4.55%)均优于与对照组,差异有统计学意义(P<0.05)。结论小儿咳嗽变异性哮喘应用孟鲁司特钠联合布地奈德治疗,疗效确切。
Objective To investigate the efficacy of montelukast combined with budesonide in the treatment of pediatric cough variant asthma. Methods Eighty-four children with cough-variant asthma admitted to Fengren District People’s Hospital of Tangshan City were enrolled in this study. They were randomly divided into observation group and control group, of which 40 cases in control group were treated with budesonide, and 44 cases in observation group The combination of montelukast sodium and budesonide treatment, two groups of three months after treatment of lung function indicators, treatment efficiency, relapse rate and medication during the adverse reactions. Results After treatment, FEV1, FVC, FEV1 / FVC, maximum and maximum expiratory flow (PEF) in the morning and evening in the observation group were improved. The effective rate of treatment (93.18 %) And recurrence rate (4.55%) were better than the control group, the difference was statistically significant (P <0.05). Conclusion Children with cough variant asthma with montelukast combined with budesonide treatment, curative effect is exact.