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[目的]探讨梅毒血清固定现象与梅毒分期的关系;比较苄星青霉素与头孢曲松对梅毒血清固定的疗效。[方法]根据近5年本院皮肤科门诊资料完整的梅毒患者资料,统计梅毒血清固定发生率和各期梅毒血清固定发生率和形成时间,并进行比较;治疗组给予头孢曲松治疗,对照组给予苄星青霉素治疗,比较2组疗效。[结果]318例梅毒患者有58例(18.24%)发生血清固定,其中一期梅毒4例(9.76%),二期梅毒20例(13.70%),潜伏梅毒34例(25.95%);潜伏梅毒血清固定形成时间比早期梅毒晚。疗效:复治6个月后,治疗组痊愈23例,有效1例,无效2例,痊愈率为88.46%;对照组痊愈20例,有效4例,无效8例,痊愈率为62.50%。[结论]梅毒血清固定发生与梅毒分期有关,病期不明的潜伏梅毒血清固定的发生率较高,加强对潜伏梅毒的早期筛查和及早治疗对防止梅毒血清固定发生具有重要意义。治疗梅毒血清固定,头孢曲松优于苄星青霉素。
[Objective] To investigate the relationship between syphilis serum fixation and syphilis staging; compare the efficacy of benzathine penicillin and ceftriaxone on syphilis serum fixation. [Methods] Based on the data of complete dermatology outpatient clinics in the past five years in our hospital, the incidence of syphilis and the incidence of syphilis were calculated and compared. The treatment group was treated with ceftriaxone, while the control group Group given benzathine penicillin treatment, the efficacy of two groups were compared. [Results] Serum was fixed in 58 cases (18.24%) of 318 syphilis patients, including 1 syphilis in 4 cases (9.76%), 20 cases in secondary syphilis (13.70%) and latent syphilis in 34 cases (25.95% Serum is formed later than the early syphilis. Efficacy: 6 months after retreatment, the treatment group cured 23 cases, 1 case effective, 2 cases ineffective, the cure rate was 88.46%; control group recovered 20 cases, 4 cases effective, 8 cases ineffective, the cure rate was 62.50%. [Conclusion] Serum syphilis is associated with staging of syphilis, and the incidence of latent syphilis is high. It is of great significance to strengthen the early screening and early treatment of latent syphilis to prevent the syphilis from being sero-fixed. Treatment of syphilis serum fixation, ceftriaxone is better than benzathine penicillin.