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目的初步探讨0~18岁儿童青少年HAV和HEV感染的流行特点、临床表现和血清学规律。方法采用ELISA对113例患者同步进行抗HAV和抗HEV血清学标志的检测，并采用临床流行病学方法进行比较分析。结果各感染组民族和性别构成差异不明显（P＞0．05），与单纯HAV感染相比，HAV/HEV混合感染组发病年龄有下移倾向（P＜0．05），临床特征极为相似，仅出现频率略有差异（P＞0．05）；与单纯HAV和HEV感染相比，HAV／HEV合并感染可明显加重肝损害（P＜0．01）。结论HAV和／或HEV感染临床表现酷似，故应联合检测抗HAVIgM和抗HEVIgM/IgC，以帮助HAV或HEV感染的早期诊断和鉴别诊断。
Objective To investigate the prevalent characteristics, clinical manifestations and serological rules of HAV and HEV among adolescents aged 0 ~ 18 years. Methods Serum markers of anti-HAV and anti-HEV were detected simultaneously in 113 patients by ELISA and compared with clinical epidemiological methods. Results There was no significant difference in the ethnic and gender composition of each infected group (P> 0.05). Compared with HAV alone, the onset age of HAV / HEV mixed infection group tended to decrease (P <0.05), and the clinical features were very similar (P> 0.05). Compared with HAV and HEV alone, HAV / HEV infection significantly increased liver damage (P <0.01). Conclusions The clinical manifestations of HAV and / or HEV infection resemble each other, so anti-HAVIgM and anti-HEVIgM / IgC should be combined to help early diagnosis and differential diagnosis of HAV or HEV infection.