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骨质疏松症是以骨量减少和骨组织微结构退化为特征而导致骨脆性增加和易于发生骨折的全身性骨骼疾病,现已成为世界各国日益关注的公共卫生问题。家系和孪生子研究表明,遗传是决定骨量的重要因素。近年来,随着分子生物学技术的发展,对参与骨代谢的蛋白质、激素及细胞因子等与骨量有关的侯选基因研究取得了一定进展。本文就这些基因多态性与骨量关系的研究进展、局限性以及前景作一简述。
Osteoporosis is a systemic bone disease characterized by osteopenia and deterioration of the microstructure of bone tissue, which leads to increased bone fragility and fracture. It has become an increasingly public health issue in various countries in the world. Family and twin studies show that inheritance is an important factor in determining the amount of bone. In recent years, with the development of molecular biology technology, some progress has been made in the study of candidate genes related to bone mass such as proteins, hormones and cytokines involved in bone metabolism. In this paper, the relationship between these genetic polymorphisms and bone mass, research progress, limitations and prospects for a brief review.