论文部分内容阅读
目的:探讨血必净注射液对AOPP患者血清TNF-a、IL-10的干预作用。方法:将40例AOPP患者随机分为两组:常规治疗组(20例)给于洗胃、胆碱酯酶复能剂、阿托品、长托宁及对症支持治疗,血必净治疗组(20例)在常规治疗的基础上加用血必净注射液,空白对照组为医院健康体检者(20例)。观察AOPP两组1、3、5、7天血清TNF-a、IL-10的变化水平。结果:两组患者在入院第一天治疗前机体炎性因子TNF-a、IL-10较空白对照组明显升高,但两组差异无统计学意义(P>0.05),两组与空白对照组比较差异均有统计学意义(P<0.01),治疗3天后血必净治疗组机体炎性因子TNF-a、IL-10较常规治疗组明显降低,两组之间差异有统计学意义(P<0.05)。结论:血必净注射液可以明显减低AOPP患者血清炎性因子的水平,改善其预后,降低死亡率。
Objective: To investigate the effect of Xuebijing injection on serum TNF-a and IL-10 in AOPP patients. Methods: Forty AOPP patients were randomly divided into two groups: conventional treatment group (n = 20), gastric lavage, cholinesterase, atropine, penehyclidine and symptomatic supportive therapy, Xuebijing group For example, Xuebijing injection was used on the basis of routine treatment, while the blank control group was healthy in the hospital (20 cases). The levels of serum TNF-a and IL-10 in AOPP two, three, five, seven days were observed. Results: Before the first day of admission, the inflammatory cytokines TNF-a and IL-10 in the two groups were significantly higher than those in the blank control group, but there was no significant difference between the two groups (P> 0.05) (P <0.01). After 3 days of treatment, the levels of inflammatory cytokines TNF-a and IL-10 in Xuebijing group were significantly lower than those in the conventional treatment group (P <0.01). The differences between the two groups were statistically significant P <0.05). Conclusion: Xuebijing injection can significantly reduce the level of serum inflammatory cytokines in AOPP patients, improve its prognosis and reduce mortality.