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目的：探讨褪黑素（MLT）对常压下慢性间歇性缺氧SD大鼠心肌的保护作用。方法将24只雄性SD大鼠（5周龄）随机分成3组：对照组、实验A组、实验B组。对照组在空气中正常饲养，实验A组和实验B组在常压慢性间歇性低氧箱内，对照组和实验B组灌服生理盐水，实验A组灌服褪黑素。8周后用光电比色法测定血清肌钙蛋白T（cTnT）的浓度和心肌钙离子ATP酶（Ca2＋-ATPase）的活性，取大鼠右心室做病理切片。结果①实验B组与实验A组比较：实验B 组的cTnT明显增加（P＜0．05），心肌组织的Ca2＋-ATPase的活性明显降低（P＜0．05）。病理切片显示，个别心肌细胞核消失，心肌细胞肥大，心肌之间有大量出血；②实验A组与对照组比较：cTnT和Ca2＋-ATPase均无明显差异（P＞0．05）。病理切片显示，心肌细胞之间有少量出血；③实验B 组与对照组比较：实验B组的cTnT明显增加（P＜0．05），心肌组织的Ca2＋-ATPase的活性明显降低（P＜0．05）。病理切片显示，个别心肌细胞核消失，心肌细胞肥大，心肌之间有大量出血。结论褪黑素对慢性间歇性缺氧心肌具有保护作用。“,”Objective To investigate whether the melatonin (melatonin,MLT)could protect SD rats’cardiac muscu-lar tissues from chronic intermittent hypoxia damage in the atmospheric pressure.Methods The 24 male,SD rats(5 weeks)were randomly divided into three groups:the Control group,the experimental group A and the experimental group B.The control group rats were fed with normally reared in the air,and the experimental group A and B rats were living in the atmospheric pressure and chronic intermittent hypoxia boxes.The control group rats and the experimental group B rats were fed with normal saline solution (NS ),and the experimental group A rats were fed with melatonin (MLT).After 8 weeks,the cTnT capacity and Ca2+-ATPase activity of each rat were detected,and the right ventri-cles were taken for pathological section.Results ①Comparison of the experimental group B and the experimental group A:The cTnT capacity of the experimental group B was increased (P<0.05),and the Ca2+-ATPase activity of the experimental group B was decreased (P0.05).There was a small amount of bleeding between myocardial.③Comparison of the experimental group B and the control group:The cTnT capacity of the experimental group B was increased (P<0.05),and the Ca2+-ATPase activity of the experimental group B was decreased (P<0.05).Individual myocardial cell nuclei disappeared.Myocardial cells were hypertrophy,and there was a large amount of bleeding in myocardial.Conclusion MLT can protect rats’cardiac muscular tissue from injury of chronic intermittent hypoxia.