【摘 要】
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OBJECTIVE:To evaluate the efficacy of Liangxue Guyuan decoction(凉血固元汤,LGD)on radia-tion-induced intestinal injury in rats,and the possi-ble underlying mech
【机 构】
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Chinese People’s Liberation Army General Hospital,Medical School of Chinese People’s Liberation Ar-m
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OBJECTIVE:To evaluate the efficacy of Liangxue Guyuan decoction(凉血固元汤,LGD)on radia-tion-induced intestinal injury in rats,and the possi-ble underlying mechanism of action.METHODS:A total of 255 male Sprague-Dawley rats were used.15 rats were assigned to the control group and the remaining 240 rats were exposed to a 60Co source at a dose of 11 Gy.Irradiated rats were randomly divided into model,dexamethasone(DXM),low-dose LGD(LGDI),and high-dose LGD(LGDh)groups and treated for 11 d.The survival rate,weight of body,intestinal pathology and the expression of toll-like receptor 4(TLR4),myeloid dif-ferentiation primary response 88(MyD88),and nu-clear factor-kappa B(NF-κB)were recorded.RESULTS:Radiation reduced the survival rate and weight of rats,destroyed the intestinal structure,in-duced an inflammatory reaction,and increased both protein and mRNA expression of TLR4,MyD88,and NF-κB in ileum.However,LGDh in-creased the survival rate,inhibited weight loss,alle-viated inflammation and improve the expression of TLR4 pathway.CONCLUSIONS:LGD increased the survival rate and inhibit weight loss of irradiated rats,and re-duced inflammation and intestinal injury.The un-derlying mechanism may involve regulation of the TLR4/MyD88/NF-KB pathway.
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