慢性丙型肝炎患者血清和肝组织中庚型肝炎病毒RNA检测

• 作 者: 于建国 侯宪荣 潘伟 张光曙 周秀梅
• 机 构: 解放军８８医院传染科,第二军医大学微生物教研室
• 出 处: 华人消化杂志
• 发表日期: 1998年07期
• 关键词: 慢性丙型肝炎 患者血清 肝组织 庚型肝炎病毒

目的了解慢性丙型肝炎（ＣＨＣ）患者血清和肝组织中庚型肝炎病毒（ＨＧＶ）感染的状况．方法用ＲＴＰＣＲ方法对４９例ＣＨＣ患者血清和其中１４例肝组织进行ＨＧＶＲＮＡ检测．结果在４９例ＣＨＣ患者的血清和其中１４例肝组织中ＨＧＶＲＮＡ阳性检出率分别为１２２％和２１４％，证实ＨＧＶ和ＨＣＶ感染在ＣＨＣ患者血清和肝组织中同时存在，而肝组织中ＨＧＶＲＮＡ阳性检出率更高，其原因同受血或其直接经血液暴露密切相关．结论ＣＨＣ患者血清和肝组织中存在ＨＧＶ感染，而且感染率较高，故应加强对献血员进行ＨＧＶＲＮＡ和ＡＬＴ筛查，以控制输血后庚型肝炎传播

Objective To investigate the status of hepatitis G virus (HGV) infection in serum and liver of patients with chronic hepatitis C (CHC). Methods HGV RNA was detected in 49 cases of CHC serum and 14 cases of liver tissue by RTPCR. Results The positive rates of HGV RNA in serum of 49 patients with CHC and in 14 of them were 122% and 214%, respectively. It was confirmed that both HGV and HCV infection coexisted in serum and liver of patients with CHC, The positive detection rate of HGVRNA in tissues is higher, which is closely related to the blood or its direct blood exposure. Conclusions There is HGV infection in the serum and liver tissue of CHC patients and the infection rate is relatively high. Therefore, blood donors should be screened for HGV RNA and ALT to control the spread of hepatitis G virus after blood transfusion