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目的:探索中药消癌平、金龙胶囊联合奥宁治疗老年巨块型原发性肝细胞性肝癌的疗效和应用价值。方法:2位老年原发性肝细胞性肝癌患者,第一例采用消癌平60 ml+5%葡萄糖液250 ml,静脉滴注16天,奥宁15-18μg/h,Civ(连续静脉泵入),16天;第二例在前一例基础上加用金龙胶囊4粒,3次/日,连续口服14天。每次治疗结束休息一周进行AFP、影像学评价和QOL评分。结果:第一例患者治疗2个周期AFP降至162.8μg/L,肿块7.9*10.2 cm,增大约18%,QOL评分48分,疗效评价SD,该患者治疗两周期后,自行转其他医院行超声聚焦刀治疗后死亡。第二例患者治疗3周期后,AFP降至1107μg/L,B超示肿瘤缩小至4.51*4.33 cm,缩小约70%,QOL评分53分,疗效评价PR,目前患者无症状。结论:消癌平、奥宁联合奥宁治疗巨块型原发性肝细胞性肝癌是一种有效的方法。
Objective: To explore the curative effect and application value of traditional Chinese medicine Xiaopengping, Jinlong Capsule and Aoning in treatment of elderly giant hepatocellular carcinoma. Methods: Two elderly patients with primary hepatocellular carcinoma (HCC) were treated with hypoxia 60 ml + 5% dextrose 250 ml, intravenous drip 16, Orenisin 15-18 μg / h, Civ (continuous venous pump Into), 16 days; the second case on the basis of the previous case with Jinlong capsule 4, 3 times / day, continuous oral 14 days. One week after the end of each treatment, AFP, imaging evaluation and QOL score were performed. Results: The AFP of the first patient dropped to 162.8 μg / L in two cycles, with a mass of 7.9 * 10.2 cm, an increase of about 18%. The QOL score was 48 and the efficacy was evaluated as SD. After two cycles of treatment, the patient turned to other hospitals Ultrasound focused knife died after treatment. The second case of patients treated for 3 cycles, AFP dropped to 1107μg / L, B ultrasound showed the tumor narrowed to 4.51 * 4.33 cm, reduced by about 70%, QOL score 53 points, the efficacy evaluation of PR, the current patients asymptomatic. Conclusion: Xiao-ping, Ao Ning combined Aonin treatment of massive hepatocellular carcinoma is an effective method.