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目的探讨了慢性心力衰竭患者血清IGF-Ⅱ，BNP和IL-22水平的变化及临床意义。方法应用放射免疫分析和酶联法对33例慢性心力衰竭患者进行了血清IGF-Ⅱ，BNP和IL-22水平检测，并与35名正常健康人作比较。结果慢性心力衰竭患者血清IGF-Ⅱ，BNP和IL-22水平均非常显著地高于正常人组（P<0.01）,且血清IGF-Ⅱ水平与BNP、IL-22水平呈显著正相关（γ=0.4922,0.5014,P<0.01）。结论检测慢性心力衰竭患者血清IGF-Ⅱ，BNP和IL-22水平的变化对探讨其发病机理、预防和指导用药均具有重要的临床价值。“,”objective To explore the clinical significance of changes of serum IGF-Ⅱ. BNP and IL-22 levels in patients with chronic heart failure. Methods Serum IGF-Ⅱ、BNP(with RIA),Serum IL-22(with ELISA)levels were determined in 33patients with chronic heart failure and 35controls. Results The serum IGF-Ⅱ.BNP and IL-22levels were signiticantly higher than those in controls(P<0.01).Serum IGF-Ⅱ levels were positively correlated with BNP、IL-22 levels (r=0.4922.0.5014.P<0.01). Conclusion The charges of serum IGF-Ⅱ、BNP and IL-22 might be helpful investigate the pathgenesis and prevention furthermore to guide treatment for chronic heart failure .