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目的:了解丽水市区0~6岁儿童血清25-羟维生素D水平。方法:对丽水市妇幼保健院儿童保健门诊2014年10月1日至2015年9月30日期间4 525例就诊的0~6岁儿童,用酶联免疫吸附试验检测其血清25-羟维生素D浓度。结果:4 525例0~6岁儿童血清25-羟维生素D均值为70.73±30.502nmol/L,0岁组最高,随着年龄增长而降低(P<0.01),不同季度中第三季度高于其它的季度,差异有统计学意义(P<0.01),男女童之间差异无统计学意义(P<0.05);维生素D充足检出率为36.71%,缺乏检出率为24.91%(其中严重缺乏检出率为0.99%),不足检出率为38.89%,但无一例儿童达到中毒水平。各年龄组维生素D缺乏检出率中0岁组最低,呈逐渐上升趋势(P<0.01),第3季度的维生素D缺乏检出率低于其它季度,差异有统计学意义(P<0.01)。结论:丽水市区0~6岁儿童25-羟维生素D缺乏率较高,随着年龄增长呈逐渐上升,3~6岁儿童缺乏更为明显,为此,预防维生素D缺乏不但是以婴幼儿为重点对象,3~6岁儿童也是我们今后预防重点对象之一。
Objective: To understand the serum level of 25-hydroxyvitamin D in 0 ~ 6 years old children in Lishui city. Methods: A total of 4 525 children aged 0-6 years who were treated in Lishui MCH center from October 1, 2014 to September 30, 2015 were enrolled in this study. Serum 25-hydroxyvitamin D concentration. Results: The average serum 25-hydroxyvitamin D in 4 525 children aged 0-6 years was 70.73 ± 30.502nmol / L, the highest in 0-year-old group, and decreased with age (P <0.01). The third quarter in different quarters was higher than Other quarters, the difference was statistically significant (P <0.01), there was no significant difference between boys and girls (P <0.05); adequate detection of vitamin D was 36.71%, the lack of detection rate of 24.91% (of which serious Lack of detection rate was 0.99%), the detection rate was 38.89%, but none of them reached the level of poisoning. The detection rate of vitamin D deficiency in each age group was the lowest in the 0-year-old group, showing an upward trend (P <0.01). The detection rate of vitamin D deficiency in the third quarter was lower than that of the other quarters (P <0.01) . Conclusion: The incidence of 25-hydroxyvitamin D deficiency in 0-6-year-old children in Lishui City is higher than that in Lishui City. It gradually increases with age and is more obvious in children aged 3-6 years. Therefore, prevention of vitamin D deficiency is not only based on infants and young children As the key target, 3-6-year-old children are also one of the key targets of our future prevention.