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虽然大多数流行病学依据提示,肝细胞癌(HCC)是由一种或多种环境致癌因子所引起的,但是遗传素质对肿癌的直接或间接作用尚不能排除。组织相容性抗原(HLA)的分析是测定对疾病遗传易感性的一种合适方法。作者对102例组织学证实为HCC的未经挑选的南非黑人进行了研究。男92例,女10例,年龄21～65,(平均37)岁,治疗前进行了组织定型。年龄与病人组相似的健康男性黑人208例作为对照。组织相容性抗原应用淋巴细胞微量细胞毒二步法测定。应用174份血清鉴定40个抗原:A位点17个,B位点20个,C位点3个。X~2试验对每个比较值用Yates校对,这种方法获得的P值为Py,该值用实验抗原总数校对值为Pc。
Although most epidemiological evidence suggests that hepatocellular carcinoma (HCC) is caused by one or more environmental carcinogens, the direct and indirect effects of genetic predisposition on cancer can not be excluded. Analysis of histocompatibility antigens (HLA) is a suitable method of determining genetic susceptibility to disease. The authors conducted a study of 102 unselected South African nosocomially confirmed HCCs. There were 92 males and 10 females, aged from 21 to 65 years (mean 37 years). Tissue stereotyping was performed before treatment. A total of 208 healthy male blacks, similar in age and patient group, served as controls. Tissue compatibility antigen using lymphocyte cytotoxicity two-step assay. Application of 174 sera to identify 40 antigens: A site 17, B site 20, C site 3. X ~ 2 test for each comparison value Yates proofreading, this method to obtain the P value of Py, the value of the total number of experimental antigens with the calibration value of Pc.