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目的观察布地奈德治疗儿童肺炎支原体肺炎(MPP)疗效,及对患儿血清IL-4及IFN-γ水平的影响。方法将120例MPP患儿随机分为观察组和对照组,每组60例,同期另选30例进行健康体检的正常儿童作为正常组。对照组采用常规抗支原体治疗,观察组在对照组治疗基础上加用布地奈德氧气雾化吸入。观察2组患儿住院期间咳嗽程度、咳喘消失时间及咳嗽改善评分、住院时间;并比较3组血清IL-4、IFN-γ水平。结果治疗后,2组患儿咳喘等临床症状均有改善(P<0.05)。观察组咳嗽改善评分、咳喘消失时间、住院时间等临床指标均优于对照组,差异均有统计学意义(P<0.05)。治疗前,观察组、对照组与正常组相比,IL-4明显升高,IFN-γ均降低,差异均有统计学意义(P<0.05)。治疗后对照组患儿IL-4升高,IFN-γ降低,差异均有统计学意义(P<0.05);观察组IFN-γ升高,IL-4降低,差异均有统计学意义(P<0.05)。结论布地奈德雾化吸入佐治MPP可改善患儿炎性因子水平,提高临床治疗效果。
Objective To observe the curative effect of budesonide on children with Mycoplasma pneumoniae pneumonia (MPP) and its influence on serum IL-4 and IFN-γ in children. Methods A total of 120 children with MPP were randomly divided into observation group and control group, 60 cases in each group. 30 normal children undergoing physical examination during the same period were selected as the normal group. The control group was treated with conventional anti-mycoplasma treatment. The observation group received budesonide oxygen inhalation on the basis of the control group. The degree of cough, the disappearance time of cough and asthma, cough improvement score and hospital stay in the two groups were observed. The serum levels of IL-4 and IFN-γ in the three groups were also compared. Results After treatment, clinical symptoms such as cough and asthma were improved in both groups (P <0.05). Observation group cough improvement score, cough and asthma disappear time, hospital stay and other clinical indicators were better than the control group, the difference was statistically significant (P <0.05). The levels of IL-4 and IFN-γ in observation group and control group before treatment were significantly higher than those in normal group (P <0.05). The levels of IL-4 and IFN-γ in the control group were significantly decreased after treatment (P <0.05), and the levels of IFN-γ and IL-4 in the observation group were significantly lower than those in the control group (P <0.05). Conclusion Budesonide inhalation of MPP treatment can improve the level of inflammatory cytokines in children and improve the clinical curative effect.