595nm染料激光联合曲安奈德及5-氟尿嘧啶治疗增生性瘢痕疗效评价及分析
[关键词]595nm染料激光;曲安奈德;5-氟尿嘧啶;增生性瘢痕
[中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455（2021）11-0065-04
Analysis and Evaluation of Effects of 595nm Pulsed Dye Laser Combined with Triamcinolone Acetonide and Fluorouracil in the Treatment of Hypertrophic Scars
LI Wei，DANG Hui，YAN Xiao-xue，MA Ying
（Department of Plastic Surgery，the First Affiliated Hospital of Air Force Medical University，Xi'an 710032，Shaanxi，China）
Abstract： Objective To study the effects of 595nm pulsed dye laser combined with triamcinolone acetonide and fluorouracil in the treatment of hypertrophic scars. Methods Eighty patients with hypertrophic scars admitted to our hospital from August 2020 to December 2020 were enrolled as the research subjects， and they were divided into study group （595nm pulsed dye laser combined with triamcinolone acetonide and fluorouracil） and control group （triamcinolone acetonide and fluorouracil） according to the random number table method. The treatment effects of the two groups were compared. The scars [Vancouver scar scale （VSS）] and degree of pain and itching [Visual analogue scale （VAS）] were compared between the two groups before treatment and after 8 weeks of treatment， and the occurrence of adverse reactions were compared between the two groups. Results After 8 weeks of treatment， there was no statistically significant difference in the effective rate between the two groups （P>0.05）. After 8 weeks of treatment， the scores of VSS and VAS scores of pain and itching in study group were significantly lower than those before treatment and those in control group during the same period （P0.05）. Conclusion 595nm pulsed dye laser combined with triamcinolone acetonide and fluorouracil has a significant efficacy in the treatment of hypertrophic scars， and it can effectively improve scars and reduce the degree of pain and itching.
Key words： 595nm pulsed dye laser; triamcinolone acetonide; 5-fluorouracil; hypertrophic scars
增生性瘢痕是皮膚科常见疾病，常见于暴力外伤、烧烫伤及手术创伤后，可累及真皮层，皮肤修复创伤时形成大量胶原蛋白及成纤维细胞，修复处于无序状态时胶原纤维排列紊乱，导致胶原蛋白过度沉积，形成瘢痕[1]。