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目的观察疏血通注射液联合奥扎格雷钠治疗急性脑梗死效果,以及对患者神经功能、血黏度的改善作用。方法选择2014年1月—2015年7月本院收治的急性脑梗死患者98例,将患者根据随机数字表法分为观察组和对照组各49例。观察组给予疏血通注射液加奥扎格雷钠治疗,对照组仅给予奥扎格雷钠治疗,两组均治疗2周。比较治疗前后两组患者的神经功能缺损程度评分血流变指标。不同治疗时间计量资料比较采用重复测量资料方差分析,两组间比较采用独立样本t检验,组内比较采用配对t检验;计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果不同治疗时间神经功能缺损评分比较,差异有统计学意义(P<0.05),与治疗前比较,治疗1、2周神经功能缺损评分显著降低,差异均有统计学意义(均P<0.05);两组患者神经功能缺损评分比较,差异有统计学意义(P<0.05)。观察组总有效率为97.96%,明显高于对照组的77.55%,差异均有统计学意义(χ2=9.496,P<0.05)。治疗后观察组全血高切黏度、血浆黏度、红细胞压积、纤维蛋白原水平[(4.34±0.20)、(1.59±0.24)m Pa·s、(44.61±2.70)%、(3.04±0.51)g/L]均显著低于对照组[(5.41±0.26)、(1.87±0.15)m Pa·s、(48.57±4.03)%、(4.23±0.46)g/L],比较差异均有统计学意义(t=22.384、6.925、5.714、12.129,均P<0.05);观察组治疗后血液流变学指标显著低于治疗前,差异均有统计学意义(均P<0.05)。结论疏血通注射液联合奥扎格雷钠治疗急性脑梗死效果优于单纯应用奥扎格雷钠治疗,可以明显改善患者的神经功能,降低血黏度。
Objective To observe the effects of Shuxuetong injection combined with ozagrel sodium in the treatment of acute cerebral infarction and the improvement of neurological function and blood viscosity in patients. Methods A total of 98 patients with acute cerebral infarction admitted from January 2014 to July 2015 in our hospital were divided into observation group (49 cases) and control group (49 cases) according to random number table. Observation group was given Shuxuetong injection of sodium ozagrel treatment, the control group was given only ozagrel sodium treatment, two groups were treated for 2 weeks. The indexes of hemorheology were compared between the two groups before and after treatment. The measurement data of different treatment time were compared using repeated measures ANOVA. The two groups were compared by independent sample t-test. The two groups were compared by paired t-test. The count data were compared byχ2 test. P <0.05 was considered statistically significant. Results There were significant differences in neurological deficit scores at different treatment time points (P <0.05). Compared with those before treatment, the neurological deficit scores at 1 and 2 weeks were significantly lower (all P <0.05) There was significant difference between the two groups in neurological deficit score (P <0.05). The total effective rate in the observation group was 97.96%, which was significantly higher than that in the control group (77.55%), the differences were statistically significant (χ2 = 9.496, P <0.05). After treatment, the values of high shear viscosity, plasma viscosity, hematocrit and fibrinogen levels in the observation group [(4.34 ± 0.20), (1.59 ± 0.24) mPa · s, (44.61 ± 2.70)%, (3.04 ± 0.51) (5.41 ± 0.26) and (1.87 ± 0.15) m Pa · s, (48.57 ± 4.03)% and (4.23 ± 0.46) g / L, respectively, which were significantly lower than those in the control group (T = 22.384,6.925,5.714,12.129, all P <0.05). The indexes of hemorrheology in observation group were significantly lower than those before treatment (all P <0.05). Conclusion Shuxuetong injection combined with ozagrel sodium in the treatment of acute cerebral infarction is better than the application of ozagrel sodium alone, can significantly improve the patient’s neurological function, reduce blood viscosity.