论文部分内容阅读
目的探讨丁苯酞注射液对急性脑梗死患者神经功能及缺血区脑血流量的影响。方法 84例颈内动脉系统急性脑梗死患者,发病在72 h以内,按照随机数字表依次进入观察组40例和对照组44例。对照组给予常规治疗,观察组在常规治疗的基础上加用丁苯酞注射液100 m L静脉滴注,2次/d;观察治疗前、治疗14 d后患者HIHSS、Barthel指数及脑血流量(Cerebral Blood Flow CBF)变化。结果 2组患者在治疗14 d后NIHSS评分较治疗前均明显减低(P<0.05),且观察组患者NIHS评分较对照组下降明显(P<0.05);2组患者BI指数明显提高(P<0.05),且观察组较与对照组比较有明显差异;2组患者脑血流量较治疗前明显升高(P<0.05),且观察组较对照组比较有明显差异(P<0.05)。Spearman相关分析显示患者脑血流量改善与临床症状改善呈正相关(r=0.57,P<0.05)。结论丁苯酞注射液治疗急性缺血性脑卒中患者,能提高缺血区脑组织血流量,从而改善临床症状。
Objective To investigate the effect of butylphthalide on neurological function and ischemic cerebral blood flow in patients with acute cerebral infarction. Methods Eighty-four patients with acute cerebral infarction of the internal carotid artery were admitted to the observation group (40 cases) and the control group (44 cases) according to random number table within 72 hours. The patients in the control group were given routine treatment. The observation group was treated with butylphthalide 100 ml intravenous drip twice a day on the basis of conventional treatment. The levels of HIHSS, Barthel index and cerebral blood flow before and 14 days after treatment were observed in the observation group. (Cerebral Blood Flow CBF) changes. Results The scores of NIHSS in both groups were significantly lower than those before treatment (P <0.05), and the scores of NIHS in the observation group were significantly lower than those in the control group (P <0.05). The BI index of the two groups was significantly increased (P < 0.05), and the observation group compared with the control group were significantly different; two groups of patients with cerebral blood flow was significantly higher than before treatment (P <0.05), and the observation group compared with the control group were significantly different (P <0.05). Spearman correlation analysis showed that there was a positive correlation between improvement of cerebral blood flow and improvement of clinical symptoms (r = 0.57, P <0.05). Conclusion Butylphthalide injection in patients with acute ischemic stroke can improve cerebral blood flow in ischemic area and improve the clinical symptoms.