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目的：探讨血清铁蛋白（Ｆｔ）、血栓素Ａ２（ＴＸＡ２）和前列环素（ＰＧＩ２）在急性心功能不全（ＡＣＩ）发病过程中的意义。方法：测定２１例急性心功能不全患者（ＡＣＩ组）治疗前和治疗后第７、１４天血清Ｆｔ、ＴＸＡ２及ＰＧＩ２的稳定代谢产物血栓素Ｂ２（ＴＸＢ２）及６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）的含量。并选择１８例无心功能不全患者作为对照组观察。结果：ＡＣＩ组治疗前血清Ｆｔ〔（５５８．１±４６．７）μｇ／Ｌ〕较同期对照组〔（２４８．２±３０．１）μｇ／Ｌ〕明显升高（Ｐ＜０．００１）；治疗后第７天即明显下降〔（３７５．５±４０．１）μｇ／Ｌ，Ｐ＜０．０１〕，至第１４天时进一步明显下降〔（２４５．５±２９．８）μｇ／Ｌ，与第７天比较，Ｐ＜０．０１〕。ＡＣＩ患者治疗前ＴＸＢ２〔（３６１．５±４９．３）ｎｇ／Ｌ〕、ＴＸＢ２／６ｋｅｔｏＰＧＦ１α〔（３．０１±０．８９）较同期对照组〔分别为（１７３．２±３９．２）ｎｇ／Ｌ和（１．３０±０．３２）〕明显升高（Ｐ均＜０．００１），治疗后ＴＸＢ２逐渐下降，至第１４天时明显下降〔（１８９．１±３９．５）ｎｇ／Ｌ，Ｐ＜０．０１〕，ＴＸＢ２／６ｋｅｔｏＰＧＦ１α（２．０９±０．?
Objective: To investigate the significance of serum ferritin (Ft), thromboxane A2 (TXA2) and prostacyclin (PGI2) in the pathogenesis of acute cardiac insufficiency (ACI). Methods: The stable metabolites TXB2 and 6ketoPGF1α of serum Ft, TXA2 and PGI2 in 21 patients with acute cardiac insufficiency (ACI group) before and after treatment for 7 and 14 days were measured. content. 18 patients with heart failure were selected as the control group. Results: The Ft 〔(558.1 ± 46.7) μg / L〕 in the ACI group was significantly higher than that in the control group 〔(248.2 ± 30.1) μg / L〕 (P0.001) (375.5 ± 40.1) μg / L, P <0.01〕 on the seventh day after treatment and further decreased significantly on the 14th day 〔(245.5 ± 29.8) μg / L , Compared with the seventh day, P <0.01〕. The TXB2 〔(361.5 ± 49.3〕 ng / L〕, TXB2 / 6ketoPGF1α 〔(3.01 ± 0.89)〕 in ACI patients before treatment were (173.2 ± 39.2) ng / L and (1.30 ± 0.32)] were significantly increased (all P <0.001). After treatment, the level of TXB2 decreased gradually and decreased significantly at the 14th day 〔(189.1 ± 39.5) ng / L , P <0.01〕, TXB2 / 6ketoPGF1α (2.09 ± 0.