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目的：揭示心脏停搏期间机体肾上腺素能受体的变化规律，为指导心肺复苏期间更加合理地使用肾上腺素能类药物提供理论依据。方法：采用窒息使大鼠全身循环骤停作为动物模型，用放射性配基结合分析方法，研究动物在心搏停止期间心脏和肾脏α１肾上腺素能受体（α１受体）的变化。动物随机分为５组：正常对照（Ａ）组、手术对照（Ｂ）组、窒息１０分钟（Ｃ）组、窒息２０分钟（Ｄ）组和窒息３０分钟（Ｅ）组。结果：心脏α１受体在Ｂ和Ｃ组分别为（２２．０９±２．８２）ｆｍｏｌ／ｍｇｐｒ和（２１．８４±２．９４）ｆｍｏｌ／ｍｇｐｒ，与Ａ组的（３３．８８±２．７８）ｆｍｏｌ／ｍｇｐｒ比较均明显下降（Ｐ均＜０．０５）。肾脏α１受体在Ｃ组为（１８．９１±２．３６）ｆｍｏｌ／ｍｇｐｒ，与Ｂ组和Ａ组的（２８．６０±３．８２）ｆｍｏｌ／ｍｇｐｒ及（２７．９３±３．４０）ｆｍｏｌ／ｍｇｐｒ比较明显下降（Ｐ均＜０．０５）。随心脏停搏时间延长，心脏和肾脏α１受体在Ｄ和Ｅ组均有增加趋势。其中，Ｅ组肾脏α１受体为（３５．２３±４．５５）ｆｍｏｌ／ｍｇｐｒ，与Ｃ组比较明显增加（Ｐ＜０．０５）。各组心脏和肾脏受体的亲和力变化不显著。结论：在心脏骤停早期，心脏和肾脏α１受体?
OBJECTIVE: To reveal the changes of adrenergic receptor during cardiac arrest and to provide a theoretical basis for guiding the rational use of adrenergic drugs during cardiopulmonary resuscitation. Methods: Asphyxiation was used to induce systemic circulatory arrest in rats as animal models. Changes in heart and kidney α1-adrenergic receptors (α1 receptors) during heart beating were studied using radioligand binding assays. The animals were randomly divided into 5 groups: normal control group (A), control group (B), asphyxia group of 10 minutes (C), asphyxia group of 20 minutes (D) and asphyxia group of 30 minutes (E). Results: Cardiac α1 receptors in group B and C were (22.09 ± 2.82) fmol / mgpr and (21.84 ± 2.94) fmol / mgpr, respectively, compared with 33.88 ± 2 in group A 78) fmol / mgpr were significantly decreased (P all <0.05). The renal α1 receptor was (18.91 ± 2.36) fmol / mgpr in group C and (28.60 ± 3.82) fmol / mgpr and (27.93 ± 3.40) in group B and group A fmol / mgpr decreased significantly (all P <0.05). With prolonged cardiac arrest, heart and kidney α1 receptors in the D and E groups have an increasing trend. The renal α1 receptor in group E was (35.23 ± 4.55) fmol / mgpr, which was significantly higher than that in group C (P <0.05). The affinity of heart and kidney receptors in each group did not change significantly. Conclusion: In the early stage of cardiac arrest, the heart and kidney α1 receptor?