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目的研究ApoAI与急性心肌梗死之间的关系及他汀类药物对ApoAI异常的治疗价值。方法将研究病例分成三组:急性心肌梗死组(AMI组)、稳定性心绞痛组(SAP组)、对照组,比较入院时ApoAI、HDL-C在三组间的差异。将AMI组根据药物剂量分成A组和B组,比较治疗前后ApoAI、HDL-C变化值在两组间的差异。结果ApoAI在三组间两两比较均有显著性差异;HDL-C在三组间两两比较均无统计学差异。治疗后ApoAI在A组与B组均增加,P<0.05;A组比B组ApoAI增加更显著,P<0.05。治疗后HDL-C在A组与B组增加均不显著,P>0.05。结论低ApoAI血症与冠心病具有相关性,在急性心肌梗死的患者中ApoAI减低更明显。低ApoAI血症与冠心病的关系较低HDL-C血症显著。短期(1周)应用辛伐他汀可以升高ApoAI浓度。
Objective To investigate the relationship between ApoAI and acute myocardial infarction (AMI) and the therapeutic value of statins for abnormal ApoAI. Methods The study was divided into three groups: AMI group, SAP group and control group. The differences of ApoAI and HDL-C between the three groups were compared. The AMI group was divided into group A and group B according to the dose of the drug. The difference of ApoAI and HDL-C before and after treatment was compared between the two groups. Results ApoAI in any of the three groups were significantly different between the two groups; HDL-C in any of the three groups were no significant difference between the two groups. ApoAI increased in group A and group B after treatment, P <0.05; ApoAI in group A increased more significantly than that in group B (P <0.05). HDL-C in group A and group B after treatment did not increase significantly, P> 0.05. Conclusion Low ApoAImia is associated with coronary heart disease, and ApoAI reduction is more obvious in patients with acute myocardial infarction. Hypoglycemia is associated with low serum levels of ApoAI and coronary heart disease. Short-term (1 week) application of simvastatin increased ApoAI concentrations.