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目的观察辛伐他汀和氨氯地平联合用药对老年单纯收缩期高血压(ISH)患者脉压(PP)的影响。方法58例老年ISH患者被随机分为两组,对照组28例用氨氯地平(5mg/d),治疗组30例用氨氯地平(5mg/d)加辛伐他汀(10mg/d),观察12周,每两周随访血压1次并记录。结果在治疗12周时,对照组PP从治疗前(72.1±9.5)mmHg降至(63.8±7.7)mmHg;治疗组PP从治疗前(71.3±8.2)mmHg降至(58.9±6.1)mmHg。治疗前后两组PP之间差异有统计学意义(P<0.01)。结论辛伐他汀和氨氯地平联合应用有助于改善老年ISH患者的PP。
Objective To observe the effects of simvastatin and amlodipine on pulse pressure (PP) in elderly patients with isolated systolic hypertension (ISH). Methods Fifty-eight elderly patients with ISH were randomly divided into two groups: control group (n = 28) received amlodipine (5 mg / d), amlodipine (5 mg / d) plus simvastatin Observe for 12 weeks and follow up blood pressure once every two weeks and record. Results At 12 weeks of treatment, PP in the control group decreased from 72.1 ± 9.5 mmHg to 63.8 ± 7.7 mmHg before treatment, and PP in the treatment group decreased from 71.3 ± 8.2 mmHg to 58.9 ± 6.1 mmHg before treatment. Before and after treatment, the difference between the two groups of PP was statistically significant (P <0.01). Conclusions The combination of simvastatin and amlodipine may be helpful to improve PP in elderly patients with ISH.