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Objective:To investigate the clinical significance of survivin in endometrial carcinoma and to investigate the relationship between the expression of survivin and Ki-67.Methods:Immunohistochemical S-P(streptavidin-biotin-peroxidase complex)method was performed to detect the expression of survivin and Ki-67 antigen in 15 cases of normal endometrium,21 cases of endometrial simple and complex hyperplasia,22 cases of endometrial atypical hyperplasia,and 61 cases of endometrial carcinoma.Results:Survivin was hardly detected in some normal endometrium in the proliferative phase and in the secretory phase.However,the level of survivin expression in atypical hyperplasia endometrium(72.73%)was higher than that in normal endometrium(7.14%)(P < 0.05),including simple and complex hyperplasia(42.38%)(P < 0.01),and was lower than that in endometrial carcinoma(90.17%)(P < 0.05).Moreover,significant correlation was present between the expression of survivin and the characteristics of endometrial carcinoma,including clinical stage,histological grade and the presence of invasion to myometrium(P < 0.05).In addition,Ki-67 antigen expression was positively correlated with survivin expression in all specimen.Ki-67 labeled indexes(LIs)in hyperplasia endometrium were significantly lower than those in atypical hyperplasia endometrium and endometrial carcinoma(P < 0.01),while there was no significant difference in Ki-67 LIs between atypical hyperplasia endometrium and endometrial carcinoma(P > 0.05).There was no significant relationship between Ki-67 LIs and the characteristics of endometrial carcinoma,including histological grade,clinical stage or the invasion to myometrium(P > 0.05).Conclusion:Survivin may participate in the onset and progression of endometrial carcinoma through inhibiting apoptosis and promoting proliferation.Survivin expression is correlated with the malignant degree and prognosis of tumor.Ki-67 is also associated with carcinogenesis and progression of endometrial carcinoma.The results suggest that survivin could be a diagnostic and prognostic marker for endometrial carcinoma and might provide pathways to treat the patients with recurrent or refractory or rudimental endometrial carcinoma.
Objective: To investigate the clinical significance of survivin in endometrial carcinoma and to investigate the relationship between the expression of survivin and Ki-67. Methods: Immunohistochemical SP (streptavidin-biotin-peroxidase complex) method was performed to detect the expression of survivin and Ki -67 antigen in 15 cases of normal endometrium, 21 cases of endometrial simple and complex hyperplasia, 22 cases of endometrial atypical hyperplasia, and 61 cases of endometrial carcinoma. Results: Survivin was hardly detected in some normal endometrium in the proliferative phase and in the The level of survivin expression in atypical hyperplasia endometrium (72.73%) was higher than that in normal inometrium (7.14%) (P <0.05), including simple and complex hyperplasia (42.38% and was lower than that in endometrial carcinoma (90.17%) (P <0.05) .Moreover, significant correlation was present between the expression of survivin and the characteristics of endometrial carci noma, including clinical stage, histological grade and the presence of invasion to myometrium (P <0.05) .In addition, Ki-67 antigen expression was positively correlated with survivin expression in all specimens. Ki-67 labeled indexes (LIs) in hyperplasia endometrium were significantly lower than those in atypical hyperplasia endometrium and endometrial carcinoma (P <0.01), while there was no significant difference in Ki-67 LIs between atypical hyperplasia endometrium and endometrial carcinoma (P> 0.05). There was no significant relationship between Ki- 67 LIs and the characteristics of endometrial carcinoma, including histological grade, clinical stage or the invasion to myometrium (P> 0.05) .Conclusion: Survivin may participate in the onset and progression of endometrial carcinoma through inhibiting apoptosis and promoting proliferation. Survivin expression is correlated with the malignant degree and prognosis of tumor. Ki-67 is also associated with carcinogenesis and progression of endometrial carcinoma.The results suggest that survivin could be a diagnostic and prognostic marker for endometrial carcinoma and might provide pathways to treat the patients with recurrent or refractory or rudimental endometrial carcinoma.