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目的探讨癫患儿血浆和脑脊液中神经肽Y(NPY)质量浓度的变化及临床意义。方法2003年7月至2004年5月,采用放射免疫分析方法测定沈阳医学院奉天医院53例癫患儿血浆和脑脊液中NPY质量浓度,其中原发性癫43例,继发性癫10例;原发性癫未经治疗者34例,治疗后仍有抽搐发作者9例,并与对照组比较。结果(1)癫患儿血浆NPY(210.57±71.28)pg/mL明显高于对照组(159.99±65.10)pg/mL,差异有显著意义(P<0.01)。(2)原发性癫与继发性癫血浆NPY[(210.57±71.28)pg/mL与(219.25±97.14)pg/mL]相比,差异无显著意义(P>0.05)。(3)原发性癫未经治疗者与治疗后仍有抽搐发作者血浆NPY[(205.57±63.89)pg/mL与(229.44±96.61)pg/mL]相比,差异无显著意义(P>0.05)。(4)癫患儿脑脊液中神经肽Y(45.81±7.39)pg/mL明显高于对照组(19.73±5.12)pg/mL,差异有显著意义(P<0.01)。结论癫患儿血浆和脑脊液中NPY质量浓度显著增高,可作为诊断癫的一项生化参考指标。
Objective To investigate the changes and clinical significance of neuropeptide Y (NPY) in plasma and cerebrospinal fluid of children with epilepsy. Methods From July 2003 to May 2004, radioimmunoassay was used to determine the concentration of NPY in plasma and cerebrospinal fluid of 53 epileptic children in Fengtian Hospital of Shenyang Medical College. Among them, 43 cases had primary epilepsy, secondary epilepsy 10 cases; 34 cases of primary epilepsy without treatment, after treatment there are still seizures in 9 cases, and compared with the control group. Results (1) The plasma NPY level in epileptic children was significantly higher than that in the control group (210.57 ± 71.28 pg / mL, 159.99 ± 65.10 pg / mL, P <0.01). (2) Compared with secondary epileptic plasma NPY [(210.57 ± 71.28) pg / mL and (219.25 ± 97.14) pg / mL] in primary epilepsy, there was no significant difference (P> 0.05). (3) There was no significant difference in NPY [(205.57 ± 63.89) pg / mL vs (229.44 ± 96.61) pg / mL] in patients with primary epilepsy without treatment and after seizures > 0.05). (4) Neuropeptide Y (45.81 ± 7.39) pg / mL in cerebrospinal fluid of children with epilepsy was significantly higher than that of the control group (19.73 ± 5.12) pg / mL, the difference was significant (P <0.01). Conclusions The concentration of NPY in plasma and cerebrospinal fluid of children with epilepsy is significantly increased, which can be used as a biochemical reference for the diagnosis of epilepsy.