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目的:探讨酒肝颗粒对酒精性肝病大鼠肝脏组织病理学变化及血清TNF-αI、L-6含量的影响,验证其对酒精性肝病的治疗作用。方法:应用不同浓度的乙醇溶液复制酒精性肝病动物模型,分别以戒酒、酒肝颗粒以及(戒酒+酒肝颗粒)3种不同方法治疗,并对各组的血清TNF-αI、L-6含量及肝脏组织病理学变化情况进行比较。结果:酒精组大鼠肝细胞出现不同程度的脂肪变性、坏死及炎症反应,且血清TNF-αI、L-6含量明显升高增加。经过4周的治疗,治疗各组的血清TNF-αI、L-6含量以及肝脏组织病理学变化具有明显改善,特别是(戒酒+酒肝颗粒)组更为显著(P<0.01)。结论:酒肝颗粒可以降低酒精性肝病时细胞因子TNF-αI、L-6含量,改善肝脏组织病理学变化,在防治酒精性肝病方面确有疗效,值得研究推广。
Objective: To investigate the effects of Jiugan Granules on liver histopathological changes and serum TNF-αI and L-6 levels in rats with alcoholic liver disease, and to verify its therapeutic effects on alcoholic liver disease. METHODS: Animal models of alcoholic liver disease were replicated with different concentrations of ethanol solution. They were treated with Ganjiu, Jiugan Granules and (Guan Jiu + Jiu Gan Granules) by three different methods. Serum TNF-αI, L- 6 Content and liver histopathological changes were compared. RESULTS: Hepatocytes of alcohol group showed different degrees of steatosis, necrosis and inflammatory reaction, and serum TNF-αI and L-6 levels increased significantly. After 4 weeks of treatment, serum TNF-αI and L-6 levels and histopathological changes in the liver were significantly improved in the treatment groups, especially in the group of drinking alcohol and liquor liver (P<0.01). Conclusion: Liquor granules can reduce the content of cytokines TNF-αI and L-6 in alcoholic liver disease, improve the histopathological changes of liver, and have a curative effect in the prevention and treatment of alcoholic liver disease. It is worthy of research and promotion.