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目的:通过检测血清血管紧张素转换酶2(ACE2)水平,分析ACE2与冠心病(CHD)不同病程之间的相关性,探讨其在CHD发生发展中的变化规律。方法:选取非CHD对照组样本85例,CHD样本174例,并按照冠状动脉狭窄严重程度分成轻度(<50%)狭窄组(ls-CHD组)、中度(50%~75%)狭窄组(ms-CHD组)和严重(≥75%)狭窄组(ss-CHD组)。通过ELISA检测所有样本血清中ACE2水平,统计分析CHD不同病程下的ACE2水平,从而探讨血清ACE2水平与CHD发生发展间的关系。结果:ls-CHD、ms-CHD和ss-CHD组血清ACE2水平均高于非CHD组,并且随着冠状动脉狭窄严重程度的加深而上升。男性血清ACE2水平要比女性的高。单一性别内,ls-CHD、ms-CHD和ss-CHD组血清ACE2水平均高于非CHD组,并有显著性差异。回归分析发现性别、糖尿病、CHD与血清ACE2水平相关,并且性别和CHD是血清ACE2水平的独立影响因素。结论:男性血清ACE2水平高于女性;与非CHD患者相比,CHD患者血清ACE2水平升高;在CHD发生发展过程中,血清ACE2水平随CHD病情的恶化而持续升高。
Objective: To investigate the relationship between ACE2 and different course of coronary heart disease (CHD) by detecting the serum level of angiotensin-converting enzyme 2 (ACE2), and to explore its change in the occurrence and development of CHD. Methods: Totally 85 cases of non-CHD control group and 174 CHD cases were divided into mild (<50%) stenosis group (ls-CHD group) and moderate (50% -75%) stenosis according to the severity of coronary stenosis Group (ms-CHD group) and severe (≥75%) stenosis group (ss-CHD group). The levels of ACE2 in serum of all samples were detected by ELISA, and the levels of ACE2 in different course of CHD were statistically analyzed to explore the relationship between the level of serum ACE2 and the occurrence and development of CHD. Results: Serum ACE2 levels in ls-CHD, ms-CHD and ss-CHD groups were significantly higher than those in non-CHD group and increased with the severity of coronary stenosis. Male serum ACE2 levels higher than women. Within single sex, serum ACE2 levels in ls-CHD, ms-CHD and ss-CHD groups were significantly higher than those in non-CHD group, with significant differences. Regression analysis found that gender, diabetes, CHD and serum ACE2 levels, and gender and CHD are independent factors of serum ACE2 levels. CONCLUSIONS: Serum levels of ACE2 in males are higher than those in females. Compared with non-CHD patients, serum ACE2 levels are elevated in CHD patients. During the development of CHD, serum ACE2 levels continue to increase with the progression of CHD.