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为评估腹腔灌注热化疗（ＩＰＨＣ）对胃肠道恶性肿瘤患者免疫功能的影响，对３２例胃肠道恶性肿瘤患者施行术后腹腔灌注热化疗，测定其外周血Ｔ淋巴细胞亚群（ＴＬＳ）和血清白细胞介素Ⅱ受体（ｓＩＬ２Ｒ）水平，与２０例健康对照者进行比较。结果：行ＩＰＨＣ前，ＣＤ＋３、ＣＤ＋４、ＣＤ＋８、ＣＤ＋４／ＣＤ＋８较对照组降低，ｓＩＬ２Ｒ升高；行ＩＰＨＣ后，ＣＤ＋３、ＣＤ＋４、ＣＤ＋８、ＣＤ＋４／ＣＤ＋８明显下降（Ｐ＜０．０１），ｓＩＬ２Ｒ降低（Ｐ＜０．０１）。结论：腹腔灌注热化疗能明显提高患者免疫功能。
To assess the effect of intraperitoneal infusion chemotherapy (IPHC) on immune function in patients with gastrointestinal cancer, 32 patients with gastrointestinal cancer were treated with intraperitoneal hyperthermic chemotherapy and their peripheral blood T-lymphocyte subsets were determined. LS) and serum interleukin-2 receptor (sIL-2R) levels were compared with 20 healthy controls. RESULTS: Before IPHC, CD+3, CD+4, CD+8, CD+4/CD+8 were lower than control group, and sIL2R was increased. After IPHC, CD+3, CD+4, CD+8, and CD+4/CD+8 were significantly decreased (P<0.01). sIL 2R decreased (P<0.01). Conclusion: Intraperitoneal infusion of thermochemotherapy can significantly improve the immune function of patients.