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目的探讨直肠癌患者血浆D-二聚体(D-dimer)和纤维蛋白原(Fib)水平变化与直肠癌疗效、预后的关系。方法取250例直肠癌患者和40例对照组(健康体检者)的静脉血,应用全自动血凝仪测定,血浆D-二聚体含量采用乳胶凝集半定量法测定,血浆纤维蛋白原含量采用Clauss法测定。结果250例直肠癌患者中,直肠癌初治组、难治转移组、治疗缓解组的血浆D-二聚体和纤维蛋白原水平明显升高,与对照组比较差别有显著性;治疗缓解组的血浆D-二聚体、纤维蛋白原水平较初治组及难治转移组有明显下降。结论血浆D-二聚体和纤维蛋白原水平变化与直肠癌的病情严重程度及预后有明显相关性,可作为直肠癌的辅助诊断及预后判断的一项早期实验室参考指标。
Objective To investigate the relationship between plasma D-dimer and fibrinogen (Fib) level in rectal cancer patients and the efficacy and prognosis of rectal cancer. Methods The venous blood of 250 patients with rectal cancer and 40 healthy controls were collected and measured by automatic coagulation analyzer. The content of plasma D-dimer was determined by latex agglutination semi-quantitative method. The content of plasma fibrinogen Clauss method. Results Among 250 rectal cancer patients, the levels of plasma D-dimer and fibrinogen in primary rectal cancer group, refractory metastasis group and remission group were significantly higher than those in control group. The remission group Of plasma D-dimer, fibrinogen level compared with the initial treatment group and refractory metastasis was significantly decreased. Conclusions The changes of plasma D-dimer and fibrinogen level are significantly correlated with the severity and prognosis of rectal cancer, which may be an early laboratory reference for the diagnosis and prognosis of rectal cancer.