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目的探讨利福平治疗结核病中造成肝损伤的临床分析。方法采用随机数字表法将114例患者分为两组,对照组采用异烟肼进行治疗,观察组在对照组的基础上加用利福平,比较治疗前后两组患者的肝功能,并根据肝损害情况将观察组患者分为损害组和非损害组,比较两组患者的年龄、性别、乙型肝炎病毒(HBV)感染情况和嗜酒情况。结果两组患者经过治疗后肝功能均受到损害,且观察组患者肝功能损害情况比对照组严重,差异有统计学意义(P<0.05);而年龄、感染HBV以及嗜酒等均为患者发生肝损害的危险因素,差异有统计学意义(P<0.05)。结论利福平在治疗结核病中具有一定的肝损伤作用,临床使用时应根据患者的实际情况制订相应的治疗方案。
Objective To investigate the clinical analysis of rifampin in treating liver injury caused by tuberculosis. Methods 114 patients were divided into two groups by random number table method, the control group was treated with isoniazid. The observation group was treated with rifampicin on the basis of the control group, and the liver function was compared between the two groups before and after treatment. Liver damage cases were divided into observation group of patients with injury and non-injury group, comparing two groups of patients age, gender, hepatitis B virus (HBV) infection and alcohol consumption. Results After treatment, the liver function of both groups was impaired, and the liver function impairment in the observation group was more serious than that in the control group (P <0.05). However, age, HBV infection and alcohol abuse were all occurred in patients The risk factors of liver damage, the difference was statistically significant (P <0.05). Conclusions Rifampicin has a certain role in liver injury in the treatment of tuberculosis. The clinical treatment should be based on the actual situation of patients to develop the appropriate treatment.