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目的探讨上皮钙粘素在胃癌组织中的表达及临床意义。方法选择2008年1月—2011年1月手术切除胃癌原发病灶的患者58例为观察组,选择同期癌旁胃粘膜组织正常的胃癌患者20例为对照组。采用免疫组织化学技术PV-6000法,比较上皮钙粘素在观察组与对照组中的表达差异。结果上皮钙粘素在观察组中的阳性表达率为20.69%,低于在对照组中的95.00%,差异有统计学意义(P<0.05);上皮钙粘素在观察组中的阳性表达与胃癌患者的性别、年龄、肿瘤的大小均没有明显相关性(均P>0.05);淋巴结转移的胃癌患者中,上皮钙粘素表达率明显低于无淋巴结转移者(P<0.05);上皮钙粘素在观察组中的表达与胃癌的临床分期及分化程度也密切相关。结论上皮钙粘素的异常表达参与了胃癌的浸润、转移过程,是判断胃癌生物学行为和患者预后的重要因素。
Objective To investigate the expression of E-cadherin in gastric carcinoma and its clinical significance. Methods Fifty-eight patients with primary gastric cancer surgically resected from January 2008 to January 2011 were selected as the observation group. Twenty patients with normal gastric cancer adjacent to gastric cancer were selected as the control group. Immunohistochemistry PV-6000 method was used to compare the expression of E-cadherin between the observation group and the control group. Results The positive rate of E-cadherin in the observation group was 20.69%, which was lower than 95.00% in the control group (P <0.05). The positive expression of E-cadherin in the observation group and There was no significant correlation between gender, age and size of gastric cancer (all P> 0.05). The expression of E-cadherin in gastric cancer with lymph node metastasis was significantly lower than that without lymph node metastasis (P <0.05) The expression of visfatin in the observation group was also closely related to the clinical stage and differentiation of gastric cancer. Conclusion The abnormal expression of E-cadherin is involved in the infiltration and metastasis of gastric cancer, which is an important factor to judge the biological behavior of gastric cancer and the prognosis of patients.