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目的了解沈阳市沈河区新生儿卡介苗接种质量、卡痕大小与结核菌素纯蛋白衍化物(PPD)阳转的关系及接种不良反应的发生情况。方法对2009—2011年在该区产院出生接种过卡介苗的1 711名新生儿采用PPD检测,测定阳转率;测定卡痕大小及所有新生儿卡介苗接种不良反应进行监测。结果 PPD阳转率达到99.36%,其中强阳性率占15.60%;卡痕的阳性(>4 mm)有936例与PPD试验阳性结果的配对χ2检验,分析看差异有统计学意义(χ2=758.05,P<0.01)。发生2例卡介苗接种不良反应。结论该地区新生儿卡介苗接种成功率达到了90%的标准;对强阳性的儿童建议追踪观察;不能用卡痕大小代替PPD试验判断卡介苗接种成功与否;提高接种人员接种技术和加强健康教育宣传,减少卡介苗接种不良反应。
Objective To investigate the relationship between neonatal BCG vaccination quality and the size of keloid marks and the positive conversion of tuberculin pure PPD in Shenhe District of Shenyang City and the incidence of adverse reactions. Methods A total of 1 711 newborns born with BCG from birth during the period from 2009 to 2011 in this district were tested for PPD by PPD and the rate of kelosis and all newborn BCG vaccination adverse reactions were monitored. Results The positive rate of PPD was 99.36%, and the positive rate was 15.60%. There were 936 positive (> 4 mm) pairedχ2 tests in positive PPD test, and the difference was statistically significant (χ2 = 758.05 , P <0.01). Two cases of BCG vaccination adverse reactions occurred. Conclusions The success rate of neonatal BCG vaccination in this area has reached 90% of the standard; recommended follow-up observation to strongly positive children; can not be used to determine the success of BCG vaccination by using the size of kappa marks instead of PPD; improve inoculation technique of vaccination staff and strengthen publicity of health education , Reduce BCG vaccination adverse reactions.